![]() MassWiz is a search algorithm developed at the Institute of Genomics and Integrative Biology available as a Windows command-line tool. It uses a mass accuracy-sensitive, probabilistic scoring model to rank peptide and protein matches. MassMatrix is a database search algorithm for tandem mass spectrometric data. Mascot performs mass spectrometry data analysis through a statistical evaluation of matches between observed and projected peptide fragments. InsPecT is an MS-alignment search algorithm available at the Center for Computational Mass Spectrometry at the University of California, San Diego Greylag is a database search algorithm developed at the Stowers Institute for Medical Research designed to perform large searches on computational clusters having hundreds of nodes. It takes in spectra in some supported input formats and writes out. ![]() CHIMERYS is developed by MSAID GmbH, a spin-off from the Technical University of Munich, and is integrated as a node in Proteome Discoverer 3.0 software.Ĭomet is a command-line database search algorithm developed at the University of Washington available for Windows and Linux. with original developments at PARC that searches MS/MS data from all types of instruments and internally employs the program Combyne, which combines peptide identifications to produce protein scores and identification probabilities.ĬHIMERYS is a cloud-native database search algorithm for data-dependent acquisition data that makes heavy use of artificial intelligence for the identification of peptides and the deconvolution of chimeric spectra. īyonic is a database search algorithm released in 2011 by Protein Metrics Inc. It was developed by Jürgen Cox and others at the Max Planck Institute of Biochemistry. It can function independently or integrated into MaxQuant, enabling analysis of large datasets on a desktop computer. It is able to assign and score complex patterns of post-translational modifications, such as highly phosphorylated peptides and accommodates extremely large databases. ![]() The former search takes place against a database containing all amino acid sequences assumed to be present in the analyzed sample, whereas the latter infers peptide sequences without knowledge of genomic data.Īndromeda, a peptide search engine based on probabilistic scoring, can handle data with arbitrarily high fragment mass accuracy. Peptide identification algorithms fall into two broad classes: database search and de novo search. ![]() In protein mass spectrometry, tandem mass spectrometry (also known as MS/MS or MS 2) experiments are used for protein/ peptide identification. Further information: protein mass spectrometry ![]()
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